Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولBeneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Huntington's disease (HD) is a neurodegenerative disorder, characterized by progressive motor and non-motor dysfunction due to degeneration of medium spiny neurons in striatum. 3-Nitropropionic acid is commonly used to induce the animal model of HD. Rice bran is supposed to have beneficial effects on mitochondrial function. The present study has been designed to explore the effect of rice bran ...
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The crude methanolic extract of the seeds of Celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In D...
متن کاملNeuroprotective Effect of Celastrus Paniculatus Seed Extract in Epilepsy and Epilepsy-Associated Cognitive Deficits
Purpose: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of Celastrus paniculatus (C- paniculatus) seed extract on seizure severity and cognitive deficit following Pentylenetetrazole (PTZ) -induced chemical kindling model. Methods: PTZ kindling model was developed by daily administration of sub-convulsive dose of PTZ 30 mg/kg for...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2017
ISSN: 1388-0209,1744-5116
DOI: 10.1080/13880209.2017.1285945